Layla Hotel is being built across three buildings at the corner of Dale Street and Sir Thomas Street.
The £30m hotel will have 83 bedrooms, a swimming pool, gym, spa, a cinema and a top- quality restaurant.
Architect Paul Falconer, of Falconer Chester Hall, said the project had taken a long time because of the complexity of knitting three buildings together, two of which were Grade II listed.
“It is on track to open in June, and is now about 80% complete,” said Mr Falconer.
“Some of the rooms are decorated and some of the big public rooms are nearly finished.”
Liverpool developers Iliad and prominent horse racing owner and businessman Dr Marwan Koukash first announced plans for the hotel in 2005.